Ketamine Nasal Spray

Description

Ketamine Nasal Spray

Ketamine nasal spray drug is a form of ketamine, a generic drug that’s been used as a form of anesthesia for many years, Dr. Anand says. buy esketamine nasal spray online

Ketamine has also been used for years in smaller doses in IV form for patients with treatment-resistant depression. But as a generic drug, it has not been put through the FDA’s review process for that use. Ketamine nasal spray

It’s actually a controlled substance (it is sometimes abused as a recreational drug — you may have heard it called Special K). Because of that, and because it can create feelings of dissociation and hallucination in people who take it, the new ketamine nasal spray will only be administered in a doctor’s office or hospital setting.

“It’s a slightly different form of ketamine and will be given as nasal puffs, but the effects are essentially the same,” Dr. Anand says. buy Esketamine nasal spray online. well port  pharmacy

A patient will go to their doctor once or twice a week to get nasal puffs of a dose of ketamine. Because they may experience disorientation or confusion immediately afterward, they will stay at the doctor’s office for two hours. They are also advised not to drive, operate machinery, or undertake a task that requires similar mental effort for the rest of the day. buy ketamine nasal spray online.

Esketamine nasal spray appears both effective and fast-acting for treatment-resistant depression,

Why is Ketamine nasal spray promising

One potential benefit of the new drug is that it’s fast-acting. People may notice a relief in symptoms within just a few hours, and it could last for several days, Dr. Anand says. Most oral antidepressants, on the other hand, can take weeks to start working.

That’s because it works in a different way from other depression drugs. “Whereas most other available antidepressants work mainly on the serotonin, norepinephrine, or dopamine systems, ketamine has major effects on glutamate, which is a different neurotransmitter that is much more prevalent in the brain,” Dr. Anand says.

Side Effects

Dizziness, dissociation, dysgeusia (change or distortion in sense of taste), vertigo, and nausea were the most common side effects of the drug. Most tended to occur shortly after dosing and cleared up within 90 minutes. However, the consensus of the study was that overall the drug was safe and tolerable.

An imperfect solution

Beyond potential side effects, ketamine does have additional drawbacks. Though it has been used safely as a short-term anesthetic and in lower doses as a short-term antidepressant, doctors don’t yet understand whether it’s safe and effective to use over many months or years.

“This drug affects a major neurochemical in the brain, and if you interfere with that long-term, we’re not sure what the effects of that are going to be,” Dr. Anand says. “It’s also a drug of addiction, and people can misuse it or overuse it.”

There’s also no guarantee that it will work in all groups of people with treatment-resistant depression. And, like other antidepressants, there’s always the chance that it could make symptoms worse. buy ketamine nasal spray online.

Esketamine was studied in five clinical trials leading up to its approval. Only one short-term trial, and its follow-up, longer-term relapse prevention trial of patients who had benefited from ketamine, produced positive results that were statistically significant, Dr. Anand says. Another study focused solely on adults over age 65 and found that the benefit of treatment with antidepressants plus ketamine in that group of patients did not reach statistical significance

Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Allergy to ketamine, history of or
• Aneurysmal vascular disease (blood vessel disease in the brain, chest, abdominal aorta, arms, and legs) or
• Arteriovenous malformation (an abnormal connection between your veins and arteries) or
• Intracerebral hemorrhage (bleeding in the brain), history of—Should not be used in patients with these conditions.

• Cardiovascular (heart or blood vessel) disease or
• Cerebrovascular (brain or blood vessel) disease or
• Heart failure or
• Psychosis (mental illness)—Use with caution. May increase the risk for more side effects.

• Drug abuse, history of or
• Heart attack, history of or
• Hypertension (high blood pressure) or
• Stroke, history of—Use with caution. May make these conditions worse.

• Hypertensive encephalopathy (brain problem caused by high blood pressure), history of—Use with caution. May increase the risk for encephalopathy.

• Liver disease, moderate—Use with caution. The effects may be increased because of the slower removal of the medicine from the body.
• Liver disease, severe—Use is not recommended in patients with this condition.
  

  Side Effects

  Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. buy ketamine nasal spray online

  Check with your doctor immediately if any of the following side effects occur:

  More common

  1. Anxiety
  2. blurred vision
  3. confusion about identity, time, and place
  4. dizziness
  5. drowsiness
  6. the feeling of constant movement of self or surroundings
  7. feeling of unreality
  8. headache
  9. lightheadedness
  10. nervousness
  11. pounding in the ears
  12. the relaxed and calm feeling
  13. sensation of spinning
  14. sense of detachment from self or body
  15. sleepiness
  16. slow or fast heartbeat
  17. unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness

  Less common

  1. Changes in patterns and rhythms of speech
  2. excitement
  3. false or unusual sense of well-being
  4. fast, pounding, or irregular heartbeat or pulse
  5. feeling abnormal or drunk
  6. frequent daytime urination
  7. nightmares or unusually vivid dreams
  8. slurred speech
  9. tremor
  10. trouble in speaking
  11. urinating small amounts of urine at a time

  Rare

  1. Changes in behavior
  2. chest pain or discomfort
  3. discouragement
  4. fast or pounding heartbeat
  5. feeling sad or empty
  6. irritability
  7. lack of appetite
  8. loss of interest or pleasure
  9. sweating
  10. thoughts of killing oneself
  11. trouble concentrating
  12. trouble sleeping

  Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

  More common

  1. Burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feelings
  2. change in or loss of taste
  3. diarrhea
  4. nasal itching, burning, or irritation
  5. nausea
  6. throat irritation
  7. vomiting

  Less common

  1. Constipation
  2. dry mouth
  3. mouth or throat pain

  Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

  Call your doctor for medical advice about side effects.